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KMID : 1235520160150010011
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Research in Vestibular Science
2016 Volume.15 No. 1 p.11 ~ p.16
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Vestibulo-Ocular Reflex Recordings of Small Rodents using a Novel Marker Array
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김미주:Kim Mi-Joo
이지연:Lee Ji-Yeon/홍의재:Hong Eui-Jae/이은지:Lee Eun-Ji/민유진:Min Yu-Jin/이동주:Lee Dong-Ju/김남범:Kim Nam-Beom/한규철:Han Gyu-Cheol
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Abstract
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Objective: Recording the nystagmus of small experimental rodents is an integral technique in vestibular research. Theoretically, the size and the shape of markers strongly affect the analysis of 3 dimensional nystagmus.
Methods: The nystagmus of 6 healthy ICR mice were recorded and their gain values were compared using 200 μm, 300 μm, 400 μm, and 600 μm isosceles triangle markers at the peak velocity of 60o/sec and 100o/sec with the rotational stimulations of 0.1 Hz, 0.2 Hz, and 0.5 Hz.
Results: The gain values of 3 different sizes of the markers showed no significant differences in horizontal- vertical-torsional component. However, it was unable to record the nystagmus with 200 μm markers since the markers were too small to be placed and stayed on the center of the pupils.
Conclusion: Technicians can decide the size of the markers from 200 to 600 ?m to record the nystagmus of mice, depending on the technicians’ skills.
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KEYWORD
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Vestibulo-ocular reflex, Marker, Video-nytagmography, Mice
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